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Multiple myeloma

ADULT

If any of the following are present or suspected, please refer the patient to the emergency department (via ambulance if necessary) or seek emergent medical advice if in a remote region.


Emergency treatment required - needs discussion with on call specialist and/or emergency department.

 

  • Symptoms of airway obstruction, SVC obstruction
  • Severe gastrointestinal (GI) bleeding
  • Bowel obstruction
  • Febrile neutropenia
  • Symptomatic hypercalcaemia
  • Other organ failure/dysfunction
  • Uncontrolled and disabling pain
  • Massive haemoptysis and/or stridor
  • Neurological signs suggestive of brain metastases or cord compression
  • Very high calcium (3.0mmol/L)
  • Severe dysphagia with dehydration
  • Biopsy proven small cell lung cancer
    • patients with symptoms of shortness of breath, deteriorating organ function
  • Metastatic germ cell tumour (GCT) confirmed (biopsy) or suspected (tumour markers)
  • Patients with severe symptoms, organ failure or life threatening complications
  • Highly aggressive lymphoma
    • Burkitt’s lymphoma
    • lymphoblastic lymphoma
  • Acute leukaemia
  • If any life threatening symptoms present (new hypercalcaemia) or severe or life threatening symptoms present (e.g. spinal cord compression, SVC compression, ureteric compression, airway compromise etc.) – then call the haematologist on call, or send direct to emergency.
  • Bone scans are usually negative for the lytic lesions seen in myeloma. Plain film skeletal survey is recommended
  • IgM monoclonal protein is exceedingly rare in myeloma and is more commonly seen in low grade lymphomas

Minimum Referral Criteria

  • Category 1
    (appointment within 30 calendar days)

    PRESENCE OF ONE IS REQUIRED

    • Abnormal serum protein electrophoresis
    • Abnormal free light chains
    • Bence Jones protein in urine

     

    AND if ANY of the following present

    • Recent onset unexplained anaemia
    • Lytic bone lesions
    • Recent unexplained mild to moderate renal impairment
  • Category 2
    (appointment within 90 calendar days)

    PRESENCE OF ONE IS REQUIRED

    • Abnormal serum protein electrophoresis
    • Abnormal free light chains
    • Bence Jones protein in urine

     

    AND if ALL of the following present

    • Well, asymptomatic patient
    • Normal FBC and chemistry
    • No history of bone pain or new unexplained back pain.

    Categorisation depends on subtype and amount of monoclonal protein

  • Category 3
    (appointment within 365 calendar days)
    • No category 3 criteria

1. Reason for request Indicate on the referral

  • To establish a diagnosis
  • For treatment or intervention
  • For advice and management
  • For specialist to take over management
  • Reassurance for GP/second opinion
  • For a specified test/investigation the GP can't order, or the patient can't afford or access
  • Reassurance for the patient/family
  • For other reason (e.g. rapidly accelerating disease progression)
  • Clinical judgement indicates a referral for specialist review is necessary

2. Essential referral information Referral will be returned without this

  • General referral information
  • Past medical history, current medications
  • Previous cancer treatment details
  • FBC, UEC, calcium
  • Serum EPP
  • Free Light Chains (FLC)

3. Additional referral information Useful for processing the referral

  • Random (ie not 24 hour) urine BJP (highly desirable)

4. Request

Patient's Demographic Details

  • Full name (including aliases)
  • Date of birth
  • Residential and postal address
  • Telephone contact number/s – home, mobile and alternative
  • Medicare number (where eligible)
  • Name of the parent or caregiver (if appropriate)
  • Preferred language and interpreter requirements
  • Identifies as Aboriginal and/or Torres Strait Islander

Referring Practitioner Details

  • Full name
  • Full address
  • Contact details – telephone, fax, email
  • Provider number
  • Date of referral
  • Signature

Relevant clinical information about the condition

  • Presenting symptoms (evolution and duration)
  • Physical findings
  • Details of previous treatment (including systemic and topical medications prescribed) including the course and outcome of the treatment
  • Body mass index (BMI)
  • Details of any associated medical conditions which may affect the condition or its treatment (e.g. diabetes), noting these must be stable and controlled prior to referral
  • Current medications and dosages
  • Drug allergies
  • Alcohol, tobacco and other drugs use

Reason for request

  • To establish a diagnosis
  • For treatment or intervention
  • For advice and management
  • For specialist to take over management
  • Reassurance for GP/second opinion
  • For a specified test/investigation the GP can't order, or the patient can't afford or access
  • Reassurance for the patient/family
  • For other reason (e.g. rapidly accelerating disease progression)
  • Clinical judgement indicates a referral for specialist review is necessary

Clinical modifiers

  • Impact on employment
  • Impact on education
  • Impact on home
  • Impact on activities of daily living
  • Impact on ability to care for others
  • Impact on personal frailty or safety
  • Identifies as Aboriginal and/or Torres Strait Islander

Other relevant information

  • Willingness to have surgery (where surgery is a likely intervention)
  • Choice to be treated as a public or private patient
  • Compensable status (e.g. DVA, Work Cover, Motor Vehicle Insurance, etc.)
  • Please note that where appropriate and where available, the referral may be streamed to an associated public allied health and/or nursing service.  Access to some specific services may include initial assessment and management by associated public allied health and/or nursing, which may either facilitate or negate the need to see the public medical specialist.

  • A change in patient circumstance (such as condition deteriorating, or becoming pregnant) may affect the urgency categorisation and should be communicated as soon as possible.

  • Please indicate in the referral if the patient is unable to access mandatory tests or investigations as they incur a cost or are unavailable locally.